Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary Targetcam kinase 2
Cell permeable: yes
General description
A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.Chen, C., et al. 1994. Science266, 291.Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
Packaging
1 mg in Plastic ampoule
Packaged under inert gas
Physical form
A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.
Reconstitution
Following initial thaw aliquot and freeze (-20°C).
Warning
Toxicity: Irritant (B)
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