InSolution KN-93

Code: 422712-1MG D2-231

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetcam kinase 2

Cell permeable: yes

General description

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Your Price
€251.60 1MG
€309.47 inc. VAT

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetcam kinase 2

Cell permeable: yes

General description

A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.Chen, C., et al. 1994. Science266, 291.Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Physical form

A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.

Reconstitution

Following initial thaw aliquot and freeze (-20°C).

Warning

Toxicity: Irritant (B)

assay≥95% (HPLC)
formliquid
InChI keyLLLQTDSSHZREGW-AATRIKPKSA-N
InChI1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
manufacturer/tradenameCalbiochem®
potency370 nM Ki
Quality Level100
shipped inwet ice
storage conditiondesiccated (hygroscopic), protect from light, OK to freeze
storage temp.−20°C
Cas Number139298-40-1
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